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KMID : 0614019990150010352
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Journal of Pharmaceutical Sciences (C.N.U.)
1999 Volume.15 No. 1 p.352 ~ p.357
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Pharmacokinetic Study of Epigallocatechin Gallate in Rats
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Kim Dong-Chool
Lim Jae-Soo
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Abstract
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Pharmacokinetics of epigallocatechin gallate(EGCG) was studied following i.v. bolus and oral administration in rats. The values of systemic clearance(CL) were 67.9±5.2 and 26. 5±1.4ml/min/kg following i.v. bolus administration of 1mg and 5mg EGCG, respectively. The values of volume of distribution at steady state (Vss) were 380±56 and 835±84ml/kg after i.v. bolus administration of 1mg and 5mg EGCG, respectively. The decrease in the value of CL and the increase in the value of V_ss as a function of EGCG dose (1mg to 5mg) suggest saturable mechanism(s) responsible for the distribution and elimination of EGCG. The fraction absorbed of EGCG after oral and intraduodenal administration of GTC were 13% and 22% of the dose, respectively. This result suggests a considerable degradation or elimination of EGCG in the gastrointestinal absorption after oral administration in rats.
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KEYWORD
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Epigallocatechin gallate, Green tea catechin, Pharmacokinetics, Rats
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